The Kanhan River originates from the high lands of Chindawara District and flows in south east direction for about 160 kms before it enters the state of Maharashtra near Raiwari village in Saoner Taluka of Nagpur District. Nagpur city is presently getting water for from two major sources namely Kanhan River (Head work located near village Juni Kamptee) &Pench Dam (through Right Bank Canal with Lifting Point at Mahadula at 48.5 Km of canal). Samples were collected from seven major locations along the stretch of river. The samples were subjected to physicochemical analysis and performed during summer, rainy and winter seasons. The physicochemical parameters of the water samples includes pH, temperature, turbidity, conductivity (EC), suspended solids (SS), total dissolved solids (TDS), total solids (TS), dissolved oxygen (DO) and biological oxygen demand (BOD). The water quality index (WQI) is used to evaluate the quality of the river water for drinking in rainy, winter and summer season.The study was carried out to examine the change in the quality of the river water due to addition of human waste discharge, industrial waste discharge into river body and the seasonal variation in the physicochemical properties of the river.