The present work deals with the analysis of physicochemical characteristics of municipal waste water of city Varanasi. Most of such water of city flow directly by means of a system of independent drains in river Varuna. Four major nalas in different areas were selected for analysis of waste water quality of city Varanasi during 2008-2009. The result revealed that physico-chemical parameters of city sewage discharged showed quite high values of pH, temperature, alkanity, BOD, COD, Chloride, nitrate , phosphate, potassium, calcium. and low level of dissolved oxygen which make the degradation of water quality of river Varuna.