Newaj river is the ‘Life Line’ for the city of Rajgarh as it is the major source of water supply for the entire city. The study represents the results of physico-chemical parameters such as pH, Dissolved Oxygen, Biological Oxygen Demand and Chemical Oxygen Demand during different seasons from Nov. 2008 to Oct. 2009. It was observed that BOD and COD increased regularly but DO decreased in summer season except reference water sampling station. BOD, COD, DO values have deviated from the standard values. These values show that river water can directly be used for irrigation and for drinking purpose, it needs treatment.