Lead is a relatively abundant metal in nature, occurring in lead minerals. The major source of lead is the combustion of leaded petrol. The most lead intake by a big city dweller is from diet 200-300 µg per day, air and water adding a further 10-15 µg per day, each of this total intake, approximately 200 µg of lead is exerted while 25 µg is stored in the bones every day. The present work deals the effect of lead on human health and its removal by Dithiazone and Atomic-Absorption Method (Chelation Extraction).