This paper presents a review and findings of the Hybrid Upflow Anaerobic Sludge Blanket (HUASB) technologies, deploying lab scale reactors for treatment of domestic and industrialwastewater. The major controlling parameters for HUASB reactors such as inert media used, pH, temperature, upflow velocity, organic loading, hydraulic residence time along with startup and granulation are highlighted for its efficient performance and achieving optimum results. Wastewater arising from a plethora of industrial activities along with its characteristics has been included in conjunction with its treatability with different types of HUASB reactors. This review study found that inert media in different types of HUASB reactors are varied in the range of 10-40% of reactor volume, the COD removal efficiency of 41-99% along with methane generation 50-75% of biogas produced. Moreover, this review paper highlighted and studied the post treatment options for enhanced effluent water quality and energy recovery. Therefore, to achieve sustainability and circular economy different types of HUASB technology with suitable post treatment can be adopted for the purpose of domestic and industrial wastewater treatment and reuse.