The people living in Ghaggar river basin are facing various waterborne diseases due to polluted water of Ghaggar River. The quality of Ghaggar river water was tested and analysed during this study. A health survey was also conducted to strengthen the work. The results undoubtedly verify that the quality of Ghaggar river water is not suitable to withstand the aquatic life and not fit for domestic uses. The low dissolved oxygen level and other checked parameters are clearly indicating it. The observed maximum values of biochemical oxygen demand (BOD₅), color, pH, total dissolved solids (TDS), chloride (Cl^-),turbidity and chemical oxygen demand (COD) were 36 mg/l, 500 ptcu, 8.6, 1321 mg/l, 161 mg/l, 301 NTU and 265 mg/l respectively. Most probable number count of river was also carried out and it shows very high number and clearly indicating that the river has bad quality of water. To understand the possible relationship between the quality of river water and water-borne diseases amongst the locals, a questionnaire survey was also carried out. The waterborne diseases observed in the study area were Jaundice, Diarrhea, Typhoid, Hepatitis, Malaria etc.