UV radiation causes various skin problems starting from reddening of skin to the change in the shape of DNA which further leads to the skin cancer. Considering harmful effect of UV radiation present study was designed to develop an environmental friendly UV protective finish for cotton fabric using Vitis vinifera leaves. Process parameters of the study were optimized using response surface methodology for getting maximum UV protection while maintaining other physical properties of the fabric. It was found that 9.038 % concentration of extract with 60 minutes of exhaustion time at 40.909oC exhaustion temperature were selected as optimum conditions for application of Vitis vinifera extract on cotton fabric. It can be concluded that application of Vitis vinifera extract on cotton fabric incorporates UV protection properties on cotton fabric which can be helpful to prevent various UV induced skin problems.