CWE / 157/2017 当前世界环境 0973 - 4929 2320 - 8031 环境研究出版社 CWE——11-00 汽油诱导的白化大鼠血液学变化及相关的肝毒性 3. 医学生物化学系 三角洲州立大学 尼日利亚 2009-07-09 10.12944 / CWE.4.1.07 卷4 卷4 49-54 摘要

用血液学和生化指标监测汽油的毒性。白化病老鼠。将大鼠分为4组,分别腹腔注射0.00、2.0、4.0、10.0g/kg汽油,分2个阶段,分别为1、2个月。每期结束时,从各组中取出大鼠进行分析。对照大鼠同样用生理盐水处理。采集血样分析血红蛋白(Hb)、堆积细胞体积(PCV)和白细胞计数(WBC)。血清酶如谷草转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)。同样监测谷胱甘肽- s -转移酶(GST)和谷胱甘肽(GSH)。Hb和PCV显著降低,特别是在第4组大鼠,接受。10kg -1汽油与对照和其他(P <0.05)。 A significant decrease in the number of white blood cells in the first month exposure to gasoline was recorded, especially in rats administered 10gkg-1gasoline. Substantial increase in the activities of liver enzymes - ALT, AST and ALP were observed in all the groups. However, GST increased marginally from first to second month in all the groups. Furthermore, there was consistent reduction in the level of GSH after the first dose in all the groups compared with control (P < 0.05).  The study demonstrates that long term exposure of rats to gasoline could induce anaemia and liver damage.

关键字 汽油 血清酶 谷胱甘肽 贫血 肝损伤